The DOE SC program in High Energy Physics (HEP) hereby announces its interest in applications to conduct cross-cutting use-inspired basic research and development (R&D) to advance accelerator science and technology (AS&T) and domestic supplier development that supports SC’s activities in physical sciences research and which is of broader benefit to other U.S. government agencies and industry. Please note that this Notice of Funding Opportunity (NOFO) is for cross-cutting R&D and domestic supplier development and that program-specific AS&T R&D is supported though NOFOs issued by each SC program.

DOE announced a request for applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate R&D workflows using novel AI models. DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, nuclear fission, nuclear fusion, biotechnology, critical materials, quantum information science, semiconductors and microelectronics, discovery science, and energy.

The Environmental Security Technology Certification Program (ESTCP) is the DoW’s
demonstration and validation program for innovative technologies that enhance military readiness, improve installation resilience, and strengthen America’s defense infrastructure. The program focuses on deploying common sense, cost-effective, and scalable solutions that ensure operational effectiveness, improve warfighter capabilities, and reduce regulatory burdens.

The DOE SC program in Basic Energy Sciences (BES) announces a re-competition of the Energy Frontier Research Center (EFRC) program. The purpose of this program is to bring together world-class teams of scientists from universities, DOE national laboratories, and other institutions to perform energy-relevant basic research with a scope and complexity beyond what is possible in single-investigator or small-group awards.

The DOE SC Established Program to Stimulate Competitive Research (EPSCoR) hereby announces its interest in receiving applications for Building EPSCoR-State/DOE-National Laboratory Partnerships. These partnerships advance understanding of the physical world by supporting fundamental, early-stage energy research collaborations with the DOE National Laboratories

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals in the foundational technologies to enable high-rate, energy efficient, decentralized nitric acid manufacturing to protect critical supply chains in the defense industrial base and redefine energetics manufacturing in contested logistics environments. Proposed research should investigate innovative approaches that enable revolutionary advances in science, devices, or systems. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice.

The Office of Nuclear Energy’s (NE) mission is to advance nuclear energy science and technology to meet U.S. energy, environmental, and economic needs. NE has identified the following goals to address challenges in the nuclear energy sector, help realize the potential of advanced technology, and leverage the unique role of the government in spurring innovation: • Keep existing U.S. nuclear reactors operating; • Deploy new nuclear reactors; • Secure and sustain our nuclear fuel cycle; and • Expand international nuclear energy cooperation. NE conducts crosscutting nuclear energy research and development…

The Office of Manufacturing and Energy Supply Chains (MESC) is issuing this NOFO to request applications for projects to design, construct, commission and operate a Rare Earth Element (REE) Demonstration Facility that demonstrates the separation of REEs from feedstock derived from acid mine drainage, mine waste, or other deleterious materials to rare earth oxides and refining into rare earth metals at a single site.

EPA’s Office of Brownfields and Land Revitalization is announcing the availability of $20 million dollars to award approximately 20 cooperative agreements for the Multipurpose Grant Program. Multipurpose Grants provide funding to carry out a range of eligible assessment and cleanup activities, including planning and additional community engagement activities. Applicants may request up to $1,000,000 to address hazardous substances and/or petroleum contamination at one or more brownfield sites. Activities carried out at each approved, eligible site may exceed $200,000.

This funding opportunity is for EXISTING APEX Accelerators to maintain an APEX Accelerator to serve as a resource for large and small businesses, including newly started businesses, to obtain procurement technical assistance. Please save the FY26 performance and financial reporting templates for future use during the period of performance, because this announcement will be archived 30 days after the closing date.

The Established Program to Stimulate Competitive Research (EPSCoR) supports the mission of the National Science Foundation (NSF) by promoting nationwide scientific progress. Through this program, NSF fosters partnerships among academic institutions, government entities, industry, and non-profits. These collaborations aim to drive long-term improvements in research infrastructure, enhance R&D capacity, and boost the research competitiveness of eligible EPSCoR jurisdictions.